Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection.

BACKGROUND: Chronic HCV infection is a leading cause of liver-related morbidity globally. The innate and adaptive immune responses are thought to be important in determining viral outcomes. Polymorphisms associated with the IFNL3 (IL28B) gene are strongly associated with spontaneous clearance and tr...

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Bibliographic Details
Main Authors: Fitzmaurice, K, Hurst, J, Dring, M, Rauch, A, McLaren, P, Günthard, H, Gardiner, C, Klenerman, P
Format: Journal article
Language:English
Published: BMJ Publishing Group 2015