Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection.

BACKGROUND: Chronic HCV infection is a leading cause of liver-related morbidity globally. The innate and adaptive immune responses are thought to be important in determining viral outcomes. Polymorphisms associated with the IFNL3 (IL28B) gene are strongly associated with spontaneous clearance and tr...

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Hlavní autoři: Fitzmaurice, K, Hurst, J, Dring, M, Rauch, A, McLaren, P, Günthard, H, Gardiner, C, Klenerman, P
Médium: Journal article
Jazyk:English
Vydáno: BMJ Publishing Group 2015