Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

Splicing factor gene mutations are the most frequent mutations found in patients with the myeloid malignancy myelodysplastic syndrome (MDS), suggesting that spliceosomal dysfunction plays a major role in disease pathogenesis. The aberrantly spliced target genes and deregulated cellular pathways asso...

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Chi tiết về thư mục
Những tác giả chính:	Pellagatti, A, Boultwood, J
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Elsevier 2016

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