Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762

The bromodomain and extraterminal (BET) protein BRD2-4 inhibitors hold therapeutic promise in preclinical models of hematologic malignancies. However, translation of these data to molecules suitable for clinical development has yet to be accomplished. Herein we expand the mechanistic understanding o...

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Bibliografiska uppgifter
Huvudupphovsmän:	Chaidos, A, Caputo, V, Gouvedenou, K, Liu, B, Marigo, I, Chaudhry, M, Rotolo, A, Tough, DF, Smithers, NN, Bassil, AK, Chapman, TD, Harker, NR, Barbash, O, Tummino, P, Al-Mahdi, N, Haynes, AC, Cutler, L, Le, B, Rahemtulla, A, Roberts, I, Kleijnen, M, Witherington, J, Parr, NJ, Prinjha, RK, Karadimitris, A
Materialtyp:	Journal article
Språk:	English
Publicerad:	American Society of Hematology 2014

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762

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