Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication

Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication

Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular pH (pHi), which is modulated by a...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Garciarena, C, Malik, A, Swietach, P, Moreno, A, Vaughan-Jones, R
Μορφή:	Journal article
Έκδοση:	Federation of American Society of Experimental Biology 2018

Παρόμοια τεκμήρια

Low and High pH Gating of Connexin43 Channels
ανά: Garciarena, C, κ.ά.
Έκδοση: (2013)

H⁺-activated Na⁺ influx in the ventricular myocyte couples Ca²⁺-signalling to intracellular pH.
ανά: Garciarena, C, κ.ά.
Έκδοση: (2013)

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH
ανά: Garciarena, C, κ.ά.
Έκδοση: (2013)

Gating of cardiac gap junctional channels at acid and alkaline pH
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.
ανά: Garciarena, C, κ.ά.
Έκδοση: (2013)

Modulation of connexin channel gating by intracellular alkalosis
ανά: Zhuang, N, κ.ά.
Έκδοση: (2007)

Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner
ανά: P. Yahuaca, κ.ά.
Έκδοση: (2000-04-01)

Connexin43 hemichannel-mediated regulation of connexin43.
ανά: Kai Li, κ.ά.
Έκδοση: (2013-01-01)

Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes
ανά: Rebecca M. Irwin, κ.ά.
Έκδοση: (2024-10-01)

Post-transcriptional regulation of connexin43 in H-Ras-transformed cells.
ανά: Mustapha Kandouz, κ.ά.
Έκδοση: (2013-01-01)

Tonabersat enhances temozolomide‐mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition
ανά: Elena N. C. Schmidt, κ.ά.
Έκδοση: (2025-03-01)

Human Marrow Stromal Cells Enhance Connexin43 Gap Junction Intercellular Communication in Cultured Astrocytes
ανά: Qi Gao, κ.ά.
Έκδοση: (2005-02-01)

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication
ανά: Amos Fumagalli, κ.ά.
Έκδοση: (2020-09-01)

Intracellular pH regulation in heart.
ανά: Vaughan-Jones, R, κ.ά.
Έκδοση: (2009)

Spatial regulation of intracellular pH in the ventricular myocyte.
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

Betacellulin regulates gap junction intercellular communication by inducing the phosphorylation of connexin 43 in human granulosa-lutein cells
ανά: Yuxi Li, κ.ά.
Έκδοση: (2023-05-01)

Plasmalogens Regulate Retinal Connexin 43 Expression and Müller Glial Cells Gap Junction Intercellular Communication and Migration
ανά: Rémi Karadayi, κ.ά.
Έκδοση: (2022-03-01)

Coculture of Embryonic Ventricular Myocytes and Mouse Embryonic Stem Cell Enhance Intercellular Signaling by Upregulation of Connexin43
ανά: Hui Li, κ.ά.
Έκδοση: (2013-07-01)

hESC expansion and stemness are independent of connexin forty-three-mediated intercellular communication between hESCs and hASC feeder cells.
ανά: Jin-Su Kim, κ.ά.
Έκδοση: (2013-01-01)

The chemistry, physiology and pathology of pH in cancer.
ανά: Swietach, P, κ.ά.
Έκδοση: (2014)

Spatial aspects of intracellular pH regulation in heart muscle.
ανά: Vaughan-Jones, R, κ.ά.
Έκδοση: (2006)

Regulation of tumor pH and the role of carbonic anhydrase 9.
ανά: Swietach, P, κ.ά.
Έκδοση: (2007)

ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer
ανά: Chen Ni, κ.ά.
Έκδοση: (2022-10-01)

pH-Dependence of extrinsic and intrinsic H(+)-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H(+) compound.
ανά: Swietach, P, κ.ά.
Έκδοση: (2007)

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1
ανά: Richards, M, κ.ά.
Έκδοση: (2019)

The relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes.
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

Modulation of connexin 43 in viral infections
ανά: Harry Scott, κ.ά.
Έκδοση: (2024-12-01)

The Role of Connexin 43 in Lung Disease
ανά: Julie A. Swartzendruber, κ.ά.
Έκδοση: (2020-12-01)

Interactive mechanism between connexin43 and Cd-induced autophagic flux blockage and gap junctional intercellular communication dysfunction in rat hepatocytes
ανά: Yuntian Duan, κ.ά.
Έκδοση: (2023-10-01)

H+ ion activation and inactivation of the ventricular gap junction: a basis for spatial regulation of intracellular pH.
ανά: Swietach, P, κ.ά.
Έκδοση: (2007)

Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications
ανά: Tatiana Zubareva, κ.ά.
Έκδοση: (2024-11-01)

Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels
ανά: Lilia Leisle, κ.ά.
Έκδοση: (2020-04-01)

Connexin-43 channels are a novel pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells
ανά: Dovmark, T, κ.ά.
Έκδοση: (2017)

Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread.
ανά: Alexander Tishchenko, κ.ά.
Έκδοση: (2025-01-01)

Author Correction: ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer
ανά: Chen Ni, κ.ά.
Έκδοση: (2023-02-01)

Experimental generation and computational modeling of intracellular pH gradients in cardiac myocytes.
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.
ανά: Hulikova, A, κ.ά.
Έκδοση: (2013)

Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions
ανά: Lina Rimkute, κ.ά.
Έκδοση: (2018-04-01)

Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
ανά: Hossein Mostafavi, κ.ά.
Έκδοση: (2014-02-01)