Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication
Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular pH (pHi), which is modulated by a...
| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Journal article |
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Federation of American Society of Experimental Biology
2018
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