Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation.

A novel methodology for the synthesis of highly substituted pyridines based on the palladium-catalyzed enolate α-alkenylation of ketones is presented; the formation of aromatic compounds is a new direction for this catalytic C-C bond forming reaction. In the key step, a protected β-haloalkenylaldehy...

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Hlavní autoři: Hardegger, L, Habegger, J, Donohoe, T
Médium: Journal article
Jazyk:English
Vydáno: American Chemical Society 2015