Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase.
N(2)-(2-Carboxyethyl)arginine synthase (CEAS), an unusual thiamin diphosphate (ThDP)-dependent enzyme, catalyses the committed step in the biosynthesis of the b-lactamase inhibitor clavulanic acid in Streptomyces clavuligerus. Crystal structures of tetrameric CEAS-ThDP in complex with the substrate...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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