FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons

<p>Several FRET (fluorescence resonance energy transfer)-based biosensors for intracellular detection of cyclic nucleotides have been designed in the past decade. However, few such biosensors are available for cGMP, and even fewer that detect low nanomolar cGMP concentrations. Our aim was to d...

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Bibliographic Details
Main Authors: Calamera, G, Li, D, Ulsund, AH, Kim, JJ, Neely, OC, Moltzau, LR, Bjørnerem, M, Paterson, D, Kim, C, Levy, FO, Andressen, KW
Format: Journal article
Language:English
Published: Nature Research 2019