The oxidation of polychlorinated benzenes by genetically engineered cytochrome P450(cam): potential applications in bioremediation
Polychlorinated aromatic compounds are persistent environmental contaminants; we describe here the redesign and engineering of the haem monooxygenase cytochrome P450(cam) to oxidise these compounds efficiently to the chlorinated phenols which are readily degraded by many micro-organisms, thus provid...
| Main Authors: | , , |
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| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
2000
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| סיכום: | Polychlorinated aromatic compounds are persistent environmental contaminants; we describe here the redesign and engineering of the haem monooxygenase cytochrome P450(cam) to oxidise these compounds efficiently to the chlorinated phenols which are readily degraded by many micro-organisms, thus providing a basis for novel systems for biological clean-up of these inert compounds. |
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