The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.

CONTEXT: Thyroid-associated ophthalmopathy (TAO) is a sight-threatening autoimmune disease in which de novo adipogenesis has been identified as a fundamental pathogenic mechanism. 11beta-Hydroxysteroid dehydrogenase 1 (11beta-HSD1) increases cortisol bioavailability and is pivotal in mediating gluco...

Full description

Bibliographic Details
Main Authors:	Tomlinson, J, Durrani, O, Bujalska, I, Gathercole, L, Tomlins, P, Reuser, T, Rose, G, Curnow, S, Stewart, P, Walker, E, Rauz, S
Format:	Journal article
Language:	English
Published:	2010

Similar Items

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
by: Bujalska, I, et al.
Published: (2008)

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
by: Bujalska, I, et al.
Published: (2007)

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
by: Tomlinson, J, et al.
Published: (2000)

Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
by: Rauz, S, et al.
Published: (2004)

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
by: Sinclair, A, et al.
Published: (2007)

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
by: Tomlinson, J, et al.
Published: (2001)

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
by: Tomlinson, J, et al.
Published: (2002)

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
by: Bujalska, I, et al.
Published: (2005)

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
by: Bujalska, I, et al.
Published: (2002)

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
by: Tomlinson, J, et al.
Published: (2004)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
by: Stewart, P, et al.
Published: (2002)

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
by: Tomlinson, J, et al.
Published: (2002)

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
by: Morgan, SA, et al.
Published: (2009)

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.
by: Gathercole, L, et al.
Published: (2013)

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
by: Bujalska, I, et al.
Published: (2006)

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
by: Swali, A, et al.
Published: (2008)

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
by: Tomlinson, J, et al.
Published: (2001)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
by: Wiegand, S, et al.
Published: (2007)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
by: Wiegand, S, et al.
Published: (2007)

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
by: Draper, N, et al.
Published: (2003)

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
by: Stewart, P, et al.
Published: (2009)

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
by: Tomlinson, J, et al.
Published: (2005)

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.
by: Quinkler, M, et al.
Published: (2004)

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
by: Tomlinson, J, et al.
Published: (2004)

Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.
by: Korbonits, M, et al.
Published: (2001)

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
by: Morgan, SA, et al.
Published: (2010)

11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome
by: Tomlinson, J, et al.
Published: (2005)

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
by: Tomlinson, J
Published: (2005)

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
by: Lukacik, P, et al.
Published: (2006)

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
by: Valsamakis, G, et al.
Published: (2004)

Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.
by: Lavery, G, et al.
Published: (2012)

Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.
by: Maser, E, et al.
Published: (1997)

Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.
by: Stimson, R, et al.
Published: (2009)

Cortisol Metabolism and Hepatic Expression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Patients with Non Alcoholic Fatty Liver Disease.
by: Ahmed, A, et al.
Published: (2010)

Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
by: Hult, M, et al.
Published: (2004)

Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
by: Oppermann, U, et al.
Published: (1997)

Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.
by: Hult, M, et al.
Published: (2001)

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
by: Tomlinson, J, et al.
Published: (2007)

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.
by: Tomlinson, J, et al.
Published: (2003)

Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
by: Oppermann, U
Published: (2006)