The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.

CONTEXT: Thyroid-associated ophthalmopathy (TAO) is a sight-threatening autoimmune disease in which de novo adipogenesis has been identified as a fundamental pathogenic mechanism. 11beta-Hydroxysteroid dehydrogenase 1 (11beta-HSD1) increases cortisol bioavailability and is pivotal in mediating gluco...

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Main Authors: Tomlinson, J, Durrani, O, Bujalska, I, Gathercole, L, Tomlins, P, Reuser, T, Rose, G, Curnow, S, Stewart, P, Walker, E, Rauz, S
格式: Journal article
语言:English
出版: 2010