Hunter to gatherer and back: immunological synapses and kinapses as variations on the theme of amoeboid locomotion.

The immunological synapse was initially defined as a stable cell-cell junction composed of three concentric supramolecular activation clusters (SMACs) enriched in particular components: a central SMAC with clustered antigen receptors and kinases, a peripheral SMAC rich in beta2 integrin adhesion mol...