The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.

The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.

CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads into distinct biological responses remains unclear. Using a soluble invariant NKT (iNKT) TCR and a newly engineered antib...

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Bibliographic Details
Main Authors: McCarthy, C, Shepherd, D, Fleire, S, Stronge, V, Koch, M, Illarionov, P, Bossi, G, Salio, M, Denkberg, G, Reddington, F, Tarlton, A, Reddy, BG, Schmidt, R, Reiter, Y, Griffiths, G, Van Der Merwe, P, Besra, G, Jones, E, Batista, F, Cerundolo, V
Format: Journal article
Language:English
Published: 2007

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