Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study

Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study

<p><strong>Background:</strong> A SARS-CoV-2 controlled human infection model (CHIM) has been successfully established in seronegative individuals using a dose of 1×101 50% tissue culture infectious dose (TCID50) pre-alpha SARS-CoV-2 virus. Given the increasing prevalence of seropo...

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Main Authors: Jackson, S, Marshall, JL, Mawer, A, Lopez-Ramon, R, Harris, SA, Satti, I, Hughes, E, Preston-Jones, H, Cabrera Puig, I, Longet, S, Tipton, T, Laidlaw, S, Doherty, RP, Morrison, H, Mitchell, R, Tanner, R, Ateere, A, Stylianou, E, Wu, M-S, Fredsgaard-Jones, TPW, Breuer, J, Rapeport, G, Ferreira, VM, Gleeson, F, Pollard, AJ, Carroll, M, Catchpole, A, Chiu, C, McShane, H, Alparaque, M, Anid, L, Barnes, E, Benamore, R, Bharti, N, Patel, B, Burns, A, Byard, N, Conway, O, Cooper, C, Crowther, C, Dunachie, SJ, Johnstone, T, Jose, J, Luciw, M, Mujadidi, Y, Nehiweze, A, Nyamunda, S, Orobiyi-Rieba, M, Parvelikudy, B, Platt, A
Format: Journal article
Language:English
Published: Elsevier 2024

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