Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement

For kinase inhibitors, intracellular target selectivity is fundamental to pharmacological mechanism. Although a number of acellular techniques have been developed to measure kinase binding or enzymatic inhibition, such approaches can fail to accurately predict engagement in cells. Here we report the...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Vasta, JD, Corona, CR, Wilkinson, J, Zimprich, CA, Hartnett, JR, Ingold, MR, Zimmerman, K, Machleidt, T, Kirkland, TA, Huwiler, KG, Ohana, RF, Slater, M, Otto, P, Cong, M, Wells, CI, Berger, B-T, Hanke, T, Glas, C, Ding, K, Drewry, DH, Huber, KVM, Willson, TM, Knapp, S, Müller, S, Meisenheimer, PL, Fan, F, Wood, KV, Robers, MB
Format:	Journal article
Sprache:	English
Veröffentlicht:	Cell Press 2017

Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement

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