Structure and inhibition of the human SNM1a and SNM1b/Apollo DNA repair exonucleases
<p>The human SNM1A and SNM1B enzymes are 5'-3' exonucleases implicated in DNA interstrand crosslink (ICL) repair. Cells deficient in SNM1A or SNM1B show increased sensitivity to clinically important crosslinking drugs such as mitomycin C (MMC). Moreover, purified SNM1A and SNM1B have...
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| Format: | Thesis |
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2015
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