Connexin-43 channels are a novel pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells
Glycolytic cancer cells produce large quantities of lactate which must be removed in order to sustain metabolism in the absence of oxidative phosphorylation. The only venting mechanism described to do this at an adequate rate is H+ -coupled lactate efflux on monocarboxylate transporters (MCTs). Outw...
| Autors principals: | , , , , |
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| Format: | Journal article |
| Publicat: |
Springer Nature
2017
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