IL-12 and IL-18 require IFN-gamma and GM-CSF signaling, and are essential for normal bone remodeling and bone mass.

Geahča maid

• IL-12 and IL-18 are both required for normal bone remodelling and normal trabecular bone mass.
  Dahkki: Sims, N, et al.
  Almmustuhtton: (2003)
• Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis.
  Dahkki: Lauw, F, et al.
  Almmustuhtton: (1999)
• Regulation of IL-18 (IFN-gamma-inducing factor) gene expression.
  Dahkki: Tone, M, et al.
  Almmustuhtton: (1997)
• IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro.
  Dahkki: Horwood, N, et al.
  Almmustuhtton: (2001)
• Synergism of glucocorticoids with granulocyte macrophage colony stimulating factor (GM-CSF) but not interferon gamma (IFN-gamma) or interleukin-4 (IL-4) on induction of HLA class II expression on human monocytes.
  Dahkki: Sadeghi, R, et al.
  Almmustuhtton: (1992)