Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological process can be controlled to enhance paclitax...

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Bibliographic Details
Main Authors: Zheng, Y, Sethi, R, Mangala, L, Taylor, C, Goldsmith, J, Wang, M, Masuda, K, Karaminejadranjbar, M, Mannion, D, Miranda, F, Herrero-Gonzalez, S, Hellner, K, Chen, F, Alsaadi, A, Albukhari, A, Fotso, D, Yau, C, Jiang, D, Pradeep, S, Rodriguez-Aguayo, C, Lopez-Berestein, G, Knapp, S, Gray, N, Campo, L, Myers, K, Dhar, S, Ferguson, D, Bast, R, Sood, A, von Delft, F, Ahmed, A
Format: Journal article
Language:English
Published: Springer Nature 2018

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