Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.

The polymixin colistin is a "last line" antibiotic against extensively-resistant Gram-negative bacteria. Recently, the mcr-1 gene was identified as a plasmid-mediated resistance mechanism in human and animal Enterobacteriaceae, with a wide geographical distribution and many producer strain...

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Bibliographic Details
Main Authors:	Hinchliffe, P, Yang, Q, Portal, E, Young, T, Li, H, Tooke, C, Carvalho, M, Paterson, N, Brem, J, Niumsup, P, Tansawai, U, Lei, L, Li, M, Shen, Z, Wang, Y, Schofield, C, Mulholland, A, Shen, J, Fey, N, Walsh, T, Spencer, J
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2017

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.

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