Oligonucleotide-functionalized gold nanoparticles for synchronous telomerase inhibition, radiosensitization, and delivery of theranostic radionuclides

Oligonucleotide-functionalized gold nanoparticles for synchronous telomerase inhibition, radiosensitization, and delivery of theranostic radionuclides

<p>Telomerase represents an attractive target in oncology as it is expressed in cancer but not in normal tissues. The oligonucleotide inhibitors of telomerase represent a promising anticancer strategy, although poor cellular uptake can restrict their efficacy. In this study, gold nanoparticles...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Bavelaar, BM, Song, L, Jackson, MR, Able, S, Tietz, O, Skaripa-Koukelli, I, Waghorn, PA, Gill, MR, Carlisle, RC, Tarsounas, M, Vallis, KA
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	American Chemical Society 2021

Ижил төстэй зүйлс

Radiolabeled oligonucleotides targeting the RNA subunit of telomerase inhibit telomerase and induce DNA damage in telomerase-positive cancer cells
-н: Jackson, MR, зэрэг
Хэвлэсэн: (2019)

Subcellular targeting of theranostic radionuclides
-н: Bavelaar, B, зэрэг
Хэвлэсэн: (2018)

Subcellular Targeting of Theranostic Radionuclides
-н: Bas M. Bavelaar, зэрэг
Хэвлэсэн: (2018-09-01)

111In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells
-н: Gill, M, зэрэг
Хэвлэсэн: (2018)

Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation
-н: Owen, J, зэрэг
Хэвлэсэн: (2019)

An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells
-н: Gill, MR, зэрэг
Хэвлэсэн: (2020)

Targeting telomerase with radiolabeled inhibitors.
-н: Waghorn, P, зэрэг
Хэвлэсэн: (2016)

Ultrasound-mediated cavitation enhances the delivery of an EGFR-targeting liposomal formulation designed for chemo-radionuclide therapy
-н: Thomas, E, зэрэг
Хэвлэсэн: (2019)

Towards the synthesis and delivery of a halogenated MCT1 substrate
-н: Skaripa-Koukelli, Eirini
Хэвлэсэн: (2019)

Telomerase-targeting radiopharmaceuticals for the selective treatment of cancer
-н: Bavelaar, B
Хэвлэсэн: (2018)

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
-н: Skaripa-Koukelli, I, зэрэг
Хэвлэсэн: (2021)

Transition metal compounds as cancer radiosensitizers
-н: Gill, M, зэрэг
Хэвлэсэн: (2018)

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
-н: Irini Skaripa-Koukelli, зэрэг
Хэвлэсэн: (2021-10-01)

Limitations of radiosensitization by direct telomerase inhibition to treat high-risk medulloblastoma
-н: Satarupa Sengupta, зэрэг
Хэвлэсэн: (2023-01-01)

Targeting micrometastases: The effect of heterogeneous radionuclide distribution on tumor control probability
-н: Falzone, N, зэрэг
Хэвлэсэн: (2018)

Radiosensitivity of colorectal cancer to 90Y and the radiobiological implications for radioembolisation therapy
-н: Lee, B, зэрэг
Хэвлэсэн: (2019)

Gadolinium-Based Nanoparticles for Theranostic MRI-Guided Radiosensitization in Hepatocellular Carcinoma
-н: Pengcheng Hu, зэрэг
Хэвлэсэн: (2019-11-01)

Population pharmacokinetics of imetelstat, a first‐in‐class oligonucleotide telomerase inhibitor
-н: Mario González‐Sales, зэрэг
Хэвлэсэн: (2024-07-01)

Targeted radionuclide therapy in combined-modality regimens
-н: Gill, M, зэрэг
Хэвлэсэн: (2017)

A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(II) metallo-intercalator
-н: Gill, MR, зэрэг
Хэвлэсэн: (2017)

Exposing the Rad to Radionuclide: Why Early Education in Theranostics Is Important to Radiologists
-н: Andy Ho, зэрэг
Хэвлэсэн: (2025-02-01)

Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc
-н: C. Shaun Loveless, зэрэг
Хэвлэсэн: (2019-05-01)

Diagnostic Performance of Theranostic Radionuclides Used in Transarterial Radioembolization for Liver Cancer
-н: Rou Li, зэрэг
Хэвлэсэн: (2021-01-01)

Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents
-н: Winuprasith T, зэрэг
Хэвлэсэн: (2023-08-01)

Megavoltage radiosensitization of gold nanoparticles on a Glioblastoma Cancer Cell Line using a clinical platform
-н: Kazmi, F, зэрэг
Хэвлэсэн: (2020)

The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker
-н: Holis Abdul Holik, зэрэг
Хэвлэсэн: (2022-05-01)

A Theoretical and Experimental study of the Theranostic Radionuclide Scandium-47 in Karaj Cyclotron
-н: A. Jafari, зэрэг
Хэвлэсэн: (2021-06-01)

Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells
-н: Tietz, O, зэрэг
Хэвлэсэн: (2022)

Copper radionuclides for theranostic applications: towards standardisation of their nuclear data. A mini-review
-н: Mazhar Hussain, зэрэг
Хэвлэсэн: (2023-09-01)

Low Proarrhythmic Risk of Imetelstat, a Novel Oligonucleotide Telomerase Inhibitor: A Translational Analysis
-н: Ashley L. Lennox, зэрэг
Хэвлэсэн: (2025-02-01)

Targeting the nucleus: an overview of Auger-electron radionuclide therapy.
-н: Cornelissen, B, зэрэг
Хэвлэсэн: (2010)

Imaging the inside of a tumour: a review of radionuclide imaging and theranostics targeting intracellular epitopes.
-н: Cornelissen, B
Хэвлэсэн: (2014)

Radionuclide targeted therapy, theranostics, and precision medicine in the era of hybrid imaging: an important pillar in cancer care
-н: Suppiah, Subapriya, зэрэг
Хэвлэсэн: (2022)

Advances in prostate-specific membrane antigen-targeted theranostics: from radionuclides to near-infrared fluorescence technology
-н: Zhongji Jiang, зэрэг
Хэвлэсэн: (2025-01-01)

The Beginning and Development of the Theranostic Approach in Nuclear Medicine, as Exemplified by the Radionuclide Pair 86Y and 90Y
-н: Frank Rösch, зэрэг
Хэвлэсэн: (2017-06-01)

Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumors.
-н: Cornelissen, B, зэрэг
Хэвлэсэн: (2013)

Accumulation of 111In-Labelled EGF-Au-PEG Nanoparticles in EGFR-Positive Tumours is Enhanced by Co-administration of Targeting Ligand
-н: Song, L, зэрэг
Хэвлэсэн: (2017)

Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads † ‡
-н: Jin, C, зэрэг
Хэвлэсэн: (2024)

Cytotoxic effect of combining two antisense oligonucleotides against telomerase rna component (hTR and mRNA of centromere protein B (CENP-B) in hepatocellular carcinoma cells
-н: AHMED M. EL-DESOKY, зэрэг
Хэвлэсэн: (2022-07-01)

Targeted radionuclide therapy for neuroendocrine tumours: principles and application.
-н: Druce, MR, зэрэг
Хэвлэсэн: (2010)