Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses.

The lung is an important entry site for pathogens; its exposure to antigens results in systemic as well as local IgA and IgG antibodies. Here we show that intranasal administration of virus-like particles (VLPs) results in splenic B-cell responses with strong local germinal-center formation. Surpris...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Bessa, J, Zabel, F, Link, A, Jegerlehner, A, Hinton, H, Schmitz, N, Bauer, M, Kündig, T, Saudan, P, Bachmann, M
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: 2012