Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses.
The lung is an important entry site for pathogens; its exposure to antigens results in systemic as well as local IgA and IgG antibodies. Here we show that intranasal administration of virus-like particles (VLPs) results in splenic B-cell responses with strong local germinal-center formation. Surpris...
| Glavni autori: | , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2012
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