Targeted hematopoietic stem cell depletion through SCF-blockade

Background: Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. However, HSCT regimens currently commonly utilize genotoxic chemotherapy and/or total body irradiation (TBI) conditioning which causes significant morbidity and mortality th...

Full description

Bibliographic Details
Main Authors: Chan, YY, Ho, PY, Dib, C, Swartzrock, L, Rayburn, M, Willner, H, Ko, E, Ho, K, Down, JD, Wilkinson, AC, Nakauchi, H, Denis, M, Cool, T, Czechowicz, A
Format: Journal article
Language:English
Published: BioMed Central 2024