Loss of programmed death ligand-1 expression on donor T cells lessens acute graft-versus-host disease lethality

The PD-1/PD-L1 pathway plays an important role in regulation of alloimmune responses and in induction and maintenance of peripheral tolerance. Because GVHD is driven by donor T cells and PD-L1 expression can be markedly elevated on T cells during activation, we investigated the functional significan...

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Bibliographic Details
Main Authors:	Saha, A, O'Connor, R, Thangavelu, G, Lovitch, S, Dandamudi, D, Wilson, C, Vincent, B, Aoyama, K, Taylor, P, Panoskaltsis-Mortari, A, Foncea, R, Burrill, J, Guo, L, Sacristan, C, Furlan, S, Snyder, N, Blair, I, Milone, M, Dustin, M, Riley, J, Bernlohr, D, Turka, L, Murphy, W, Fife, B, Munn, D, Miller, J, Serody, J, Kean, L, Freeman, G, Sharpe, A, Blazar, B
Format:	Conference item
Published:	American Society of Hematology 2015

Loss of programmed death ligand-1 expression on donor T cells lessens acute graft-versus-host disease lethality

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