Metal-free oxidative fluorination of phenols with [18F]fluoride.
The radiochemical synthesis of [18F]4-fluorophenols is based on phenol umpolung under oxidative conditions and direct nucleophilic fluorination with [18F]fluoride (see scheme, TBAF=tetra-n-butylammonium fluoride, TFA=trifluoroacetic acid). Readily available O-unprotected 4-tert-butyl phenols are use...
| Glavni autori: | , , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2012
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| _version_ | 1826304036104568832 |
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| author | Gao, Z Lim, Y Tredwell, M Li, L Verhoog, S Hopkinson, M Kaluza, W Collier, T Passchier, J Huiban, M Gouverneur, V |
| author_facet | Gao, Z Lim, Y Tredwell, M Li, L Verhoog, S Hopkinson, M Kaluza, W Collier, T Passchier, J Huiban, M Gouverneur, V |
| author_sort | Gao, Z |
| collection | OXFORD |
| description | The radiochemical synthesis of [18F]4-fluorophenols is based on phenol umpolung under oxidative conditions and direct nucleophilic fluorination with [18F]fluoride (see scheme, TBAF=tetra-n-butylammonium fluoride, TFA=trifluoroacetic acid). Readily available O-unprotected 4-tert-butyl phenols are used as precursors in this one-pot protocol. The reaction is completed in less than 30 minutes at room temperature and can be performed using standard or microfluidic technology. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. |
| first_indexed | 2024-03-07T06:11:44Z |
| format | Journal article |
| id | oxford-uuid:efbda8be-25ad-4ed1-b947-cc72f77ece15 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:11:44Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:efbda8be-25ad-4ed1-b947-cc72f77ece152022-03-27T11:42:27ZMetal-free oxidative fluorination of phenols with [18F]fluoride.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:efbda8be-25ad-4ed1-b947-cc72f77ece15EnglishSymplectic Elements at Oxford2012Gao, ZLim, YTredwell, MLi, LVerhoog, SHopkinson, MKaluza, WCollier, TPasschier, JHuiban, MGouverneur, VThe radiochemical synthesis of [18F]4-fluorophenols is based on phenol umpolung under oxidative conditions and direct nucleophilic fluorination with [18F]fluoride (see scheme, TBAF=tetra-n-butylammonium fluoride, TFA=trifluoroacetic acid). Readily available O-unprotected 4-tert-butyl phenols are used as precursors in this one-pot protocol. The reaction is completed in less than 30 minutes at room temperature and can be performed using standard or microfluidic technology. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. |
| spellingShingle | Gao, Z Lim, Y Tredwell, M Li, L Verhoog, S Hopkinson, M Kaluza, W Collier, T Passchier, J Huiban, M Gouverneur, V Metal-free oxidative fluorination of phenols with [18F]fluoride. |
| title | Metal-free oxidative fluorination of phenols with [18F]fluoride. |
| title_full | Metal-free oxidative fluorination of phenols with [18F]fluoride. |
| title_fullStr | Metal-free oxidative fluorination of phenols with [18F]fluoride. |
| title_full_unstemmed | Metal-free oxidative fluorination of phenols with [18F]fluoride. |
| title_short | Metal-free oxidative fluorination of phenols with [18F]fluoride. |
| title_sort | metal free oxidative fluorination of phenols with 18f fluoride |
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