Fibroblasts as efficient antigen-presenting cells in lymphoid organs.
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of ho...
| Autors principals: | , , , , , , , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
1995
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| _version_ | 1826304041039167488 |
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| author | Kündig, T Bachmann, M DiPaolo, C Simard, J Battegay, M Lother, H Gessner, A Kühlcke, K Ohashi, P Hengartner, H |
| author_facet | Kündig, T Bachmann, M DiPaolo, C Simard, J Battegay, M Lother, H Gessner, A Kühlcke, K Ohashi, P Hengartner, H |
| author_sort | Kündig, T |
| collection | OXFORD |
| description | Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies. |
| first_indexed | 2024-03-07T06:11:48Z |
| format | Journal article |
| id | oxford-uuid:efc3a99c-2c2b-481e-865b-a15ff23242a8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:11:48Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:efc3a99c-2c2b-481e-865b-a15ff23242a82022-03-27T11:42:39ZFibroblasts as efficient antigen-presenting cells in lymphoid organs.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:efc3a99c-2c2b-481e-865b-a15ff23242a8EnglishSymplectic Elements at Oxford1995Kündig, TBachmann, MDiPaolo, CSimard, JBattegay, MLother, HGessner, AKühlcke, KOhashi, PHengartner, HOnly so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies. |
| spellingShingle | Kündig, T Bachmann, M DiPaolo, C Simard, J Battegay, M Lother, H Gessner, A Kühlcke, K Ohashi, P Hengartner, H Fibroblasts as efficient antigen-presenting cells in lymphoid organs. |
| title | Fibroblasts as efficient antigen-presenting cells in lymphoid organs. |
| title_full | Fibroblasts as efficient antigen-presenting cells in lymphoid organs. |
| title_fullStr | Fibroblasts as efficient antigen-presenting cells in lymphoid organs. |
| title_full_unstemmed | Fibroblasts as efficient antigen-presenting cells in lymphoid organs. |
| title_short | Fibroblasts as efficient antigen-presenting cells in lymphoid organs. |
| title_sort | fibroblasts as efficient antigen presenting cells in lymphoid organs |
| work_keys_str_mv | AT kundigt fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT bachmannm fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT dipaoloc fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT simardj fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT battegaym fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT lotherh fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT gessnera fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT kuhlckek fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT ohaship fibroblastsasefficientantigenpresentingcellsinlymphoidorgans AT hengartnerh fibroblastsasefficientantigenpresentingcellsinlymphoidorgans |