The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

Antimicrobial peptides (AMPs) offer a promising solution to the antibiotic resistance crisis. However, an unresolved serious concern is that the evolution of resistance to therapeutic AMPs may generate cross-resistance to host AMPs, compromising a cornerstone of the innate immune response. We system...

Full description

Bibliographic Details
Main Authors: Jangir, PK, Ogunlana, L, Szili, P, Czikkely, M, Shaw, LP, Stevens, EJ, Yang, Y, Yang, Q, Wang, Y, Pál, C, Walsh, TR, MacLean, CR
Format: Journal article
Language:English
Published: eLife Sciences Publications 2023