Safety and Efficacy of Novel Malaria Vaccine Regimens of RTS,S/AS01B alone, or with Concomitant ChAd63-MVA Vectored Vaccines Expressing ME-TRAP

We assessed a combination multi-stage malaria vaccine schedule in which RTS,S/AS01B was given concomitantly with viral vectors expressing multiple-epitope thrombospondin-related adhesion protein (ME-TRAP) in a 0-month, 1-month, and 2-month schedule. RTS,S/AS01B was given as either three full doses o...

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Main Authors: Rampling, T, Ewer, KJ, Bowyer, G, Edwards, N, Wright, D, Sridhar, S, Payne, R, Powlson, J, Bliss, C, Venkatraman, N, Poulton, I, de Graaf, H, Gbesemete, D, Grobbelaar, A, Davis, H, Roberts, R, Angus, B, Ivinson, K, Weltzin, R, Rajkumar, B-Y, Wille-Reece, U, Lee, C, Ockenhouse, C, Sinden, R, Gerry, S, Lawrie, A, Vekemans, J, Morelle, D, Lievens, M, Ballou, RW, Lewis, DJM, Cooke, GS, Faust, SN, Gilbert, S, Hill, A
Format: Journal article
Published: Nature Publishing Group 2018