Comparison of thymocyte development in normal and invariant chain-deficient mice provides evidence that maturation-related changes in TCR and co-receptor levels play a critical role in cell fate.

Comparison of thymocyte development in normal and invariant chain-deficient mice provides evidence that maturation-related changes in TCR and co-receptor levels play a critical role in cell fate.

Cells of invariant chain-deficient mice show a substantial decrease in cell surface MHC class II protein expression, as well as a change in the occupancy of the expressed class II molecules. Taking advantage of recent advances in phenotypic identification of transitional populations of developing th...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Huang, L, van Meerwijk, J, Bikoff, E, Germain, R
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	1996

समान संसाधन

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation
द्वारा: Hyewon Phee, और अन्य
प्रकाशित: (2014-05-01)

SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision
द्वारा: Ce Ji, और अन्य
प्रकाशित: (2022-01-01)

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.
द्वारा: Bikoff, E, और अन्य
प्रकाशित: (1993)

The molecular signature underlying the thymic migration and maturation of TCRαβ+ CD4+ CD8 thymocytes.
द्वारा: Fei Teng, और अन्य
प्रकाशित: (2011-01-01)

Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytes.
द्वारा: Marielle C Gold, और अन्य
प्रकाशित: (2008-02-01)

Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection.
द्वारा: Mariathasan, S, और अन्य
प्रकाशित: (1998)

Allelic differences affecting invariant chain dependency of MHC class II subunit assembly.
द्वारा: Bikoff, E, और अन्य
प्रकाशित: (1995)

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.
द्वारा: Shitara, S, और अन्य
प्रकाशित: (2013)

Dissecting MHC class II export, B cell maturation, and DM stability defects in invariant chain mutant mice.
द्वारा: Koonce, C, और अन्य
प्रकाशित: (2004)

Maturation and Emigration of Single-Positive Thymocytes
द्वारा: Xi Xu, और अन्य
प्रकाशित: (2013-01-01)

Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress
द्वारा: Tim I. M. Malcolm, और अन्य
प्रकाशित: (2016-01-01)

New insights into developmental fate decisions by autoreactive CD4 thymocytes
द्वारा: Xuguang Tai, और अन्य
प्रकाशित: (2024-02-01)

BALB/c invariant chain mutant mice display relatively efficient maturation of CD4+ T cells in the periphery and secondary proliferative responses elicited upon peptide challenge.
द्वारा: Kenty, G, और अन्य
प्रकाशित: (1999)

Influence of invariant chain and H-2M deficiencies in antigen processing and T cell activation in autoimmune encephalomyelitis.
द्वारा: Slavin, A, और अन्य
प्रकाशित: (2000)

Cross-Linking the TCR Complex Induces Apoptosis in CD4+8+ Thymocytes in the Presence of Cyclosporin A
द्वारा: Heather L. Poetschke, और अन्य
प्रकाशित: (1996-01-01)

Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity.
द्वारा: Slavin, A, और अन्य
प्रकाशित: (2001)

Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.
द्वारा: Takeshi Egawa, और अन्य
प्रकाशित: (2008-01-01)

Invariant chain regulation of MHC class II function in the secretory and endocytic pathways
द्वारा: Germain, R, और अन्य
प्रकाशित: (1997)

The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression
द्वारा: Meng Xu, और अन्य
प्रकाशित: (2024-03-01)

Regulation of T Helper Cell Fate by TCR Signal Strength
द्वारा: Nayan D. Bhattacharyya, और अन्य
प्रकाशित: (2020-05-01)

Stoichiometry and intracellular fate of TRIM-containing TCR complexes
द्वारा: Dopfer Elaine P, और अन्य
प्रकाशित: (2010-03-01)

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.
द्वारा: Bonnerot, C, और अन्य
प्रकाशित: (1994)

Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells
द्वारा: Chan-Su Park, और अन्य
प्रकाशित: (2024-08-01)

Requirement for antigen processing and influence of invariant chain and H-2M deficiencies on T-Cell activation in autoimmune encephalomyelitis
द्वारा: Slavin, A, और अन्य
प्रकाशित: (2001)

Correction to “The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression”
द्वारा: Meng Xu, और अन्य
प्रकाशित: (2024-08-01)

The Programmed Cell Death of an Immature ThymocyteCell Line Transgenic for an αβ TCR and the c-mycProto-Oncogene
द्वारा: Marianna Murdjeva, और अन्य
प्रकाशित: (1995-01-01)

Clonal dynamics underlying the skewed CD4/CD8 ratio of mouse thymocytes revealed by TCR-independent barcoding
द्वारा: Norimasa Iwanami, और अन्य
प्रकाशित: (2022-09-01)

MATURATION AND MIGRATION OF MURINE CD4 SINGLE POSITIVE THYMOCYTES AND THYMIC EMIGRANTS
द्वारा: Xi Xu, और अन्य
प्रकाशित: (2014-03-01)

How Many Thymic Epithelial Cells Are Necessary for a Proper Maturation of Thymocytes?
द्वारा: Sara Montero-Herradón, और अन्य
प्रकाशित: (2021-03-01)

Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes
द्वारा: Stéphanie Gon, और अन्य
प्रकाशित: (2018-06-01)

MHC class II-associated invariant chain isoforms regulate pulmonary immune responses.
द्वारा: Ye, Q, और अन्य
प्रकाशित: (2003)

MHC class II expression in double mutant mice lacking invariant chain and DM functions.
द्वारा: Kenty, G, और अन्य
प्रकाशित: (1998)

The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice.
द्वारा: Wright, R, और अन्य
प्रकाशित: (1998)

In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.
द्वारा: Takaesu, N, और अन्य
प्रकाशित: (1997)

Loss of invariant chain protects nonobese diabetic mice against type 1 diabetes.
द्वारा: Mellanby, R, और अन्य
प्रकाशित: (2006)

Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules
द्वारा: Janine Dilchert, और अन्य
प्रकाशित: (2022-05-01)

The Accessory Molecule Lgp55 Plays a Role Early in Murine Fetal Thymocyte Differentiation
द्वारा: Marcia Mcduffie, और अन्य
प्रकाशित: (1994-01-01)

Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus.
द्वारा: Matthieu Rousseau, और अन्य
प्रकाशित: (2015-01-01)

Deficiency of Antigen Presenting Cell Invariant Chain Reduces Atherosclerosis in Mice
द्वारा: Ploegh, Hidde, और अन्य
प्रकाशित: (2012)

Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
द्वारा: Leonardo JM Carvalho, और अन्य
प्रकाशित: (2006-08-01)