Aggrecanases in cartilage matrix breakdown
In rheumatoid arthritis and osteoarthritis, the loss of extracellular matrix macromolecules, aggrecan and collagens exceeds new production, resulting in serious joint impairment. The primary cause of this loss is due to elevated proteolytic enzyme activities. Recent studies have suggested that the e...
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2001
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