The molecular pathogenesis of FUS mutations in amyotrophic lateral sclerosis using in vivo and in vitro models

<p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by degeneration of both upper and lower motor neurons. Most ALS occurs in a sporadic manner, though 5-10% is familial. Fused in sarcoma (FUS) is an RNA binding protein, and mutations in the FUS gene are respon...