Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-function in human fibrosis (Jones et al., 2018). Here, th...
Những tác giả chính: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
eLife
2022
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