Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-function in human fibrosis (Jones et al., 2018). Here, th...

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Hlavní autoři: Brereton, CJ, Yao, L, Davies, ER, Zhou, Y, Vukmirovic, M, Bell, JA, Wang, S, Ridley, RA, Dean, LSN, Andriotis, OG, Conforti, F, Brewitz, L, Mohammed, S, Wallis, T, Tavassoli, A, Ewing, RM, Alzetani, A, Marshall, BG, Fletcher, SV, Thurner, PJ, Fabre, A, Kaminski, N, Richeldi, L, Bhaskar, A, Schofield, CJ, Loxham, M, Davies, DE, Wang, Y, Jones, MG
Médium: Journal article
Jazyk:English
Vydáno: eLife 2022

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