Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-function in human fibrosis (Jones et al., 2018). Here, th...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Brereton, CJ, Yao, L, Davies, ER, Zhou, Y, Vukmirovic, M, Bell, JA, Wang, S, Ridley, RA, Dean, LSN, Andriotis, OG, Conforti, F, Brewitz, L, Mohammed, S, Wallis, T, Tavassoli, A, Ewing, RM, Alzetani, A, Marshall, BG, Fletcher, SV, Thurner, PJ, Fabre, A, Kaminski, N, Richeldi, L, Bhaskar, A, Schofield, CJ, Loxham, M, Davies, DE, Wang, Y, Jones, MG
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	eLife 2022

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Míreanna comhchosúla