A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure

Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-w...

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Main Authors: Sung, YJ, Winkler, TW, de Las Fuentes, L, Bentley, AR, Brown, MR, Kraja, AT, Schwander, K, Ntalla, I, Guo, X, Franceschini, N, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Marten, J, Musani, SK, Li, C, Feitosa, MF, Kilpeläinen, TO, Richard, MA, Noordam, R, Aslibekyan, S, Aschard, H, Bartz, TM, Dorajoo, R, Liu, Y, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Tayo, BO, Warren, HR, Zhao, W, Zhou, Y, Matoba, N, Sofer, T, Alver, M, Amini, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Gandin, I, Gao, C, Giulianini, F, Goel, A, Harris, SE, Hartwig, FP, Horimoto, ARVR, Hsu, F-C, Jackson, AU, Kähönen, M, Kasturiratne, A, Kühnel, B, Leander, K, Lee, W-J, Lin, K-H, Luan, J, McKenzie, CA, Meian, H, Nelson, CP, Rauramaa, R, Schupf, N, Scott, RA, Sheu, WHH, Stančáková, A, Takeuchi, F, van der Most, PJ, Varga, TV, Wang, H, Wang, Y, Ware, EB, Weiss, S, Wen, W, Yanek, LR, Zhang, W, Zhao, JH, Afaq, S, Alfred, T, Amin, N, Arking, D, Aung, T, Barr, RG, Bielak, LF, Boerwinkle, E, Bottinger, EP, Braund, PS, Brody, JA, Broeckel, U, Cabrera, CP, Cade, B, Caizheng, Y, Campbell, A, Canouil, M, Chakravarti, A, Chauhan, G, Christensen, K, Cocca, M, Collins, FS, Connell, JM, de Mutsert, R, de Silva, HJ, Debette, S, Dörr, M, Duan, Q, Eaton, CB, Ehret, G, Evangelou, E, Faul, JD, Fisher, VA, Forouhi, NG, Franco, OH, Friedlander, Y, Gao, H, Gigante, B, Graff, M, Gu, CC, Gu, D, Gupta, P, Hagenaars, SP, Harris, TB, He, J, Heikkinen, S, Heng, C-K, Hirata, M, Hofman, A, Howard, BV, Hunt, S, Irvin, MR, Jia, Y, Joehanes, R, Justice, AE, Katsuya, T, Kaufman, J, Kerrison, ND, Khor, CC, Koh, W-P, Koistinen, HA, Komulainen, P, Kooperberg, C, Krieger, JE, Kubo, M, Kuusisto, J, Langefeld, CD, Langenberg, C, Launer, LJ, Lehne, B, Lewis, CE, Li, Y, Lim, SH, Lin, S, Liu, C-T, Liu, J, Liu, K, Loh, M, Lohman, KK, Long, J, Louie, T, Mägi, R, Mahajan, A, Meitinger, T, Metspalu, A, Milani, L, Momozawa, Y, Morris, AP, Mosley, TH, Munson, P, Murray, AD, Nalls, MA, Nasri, U, Norris, JM, North, K, Ogunniyi, A, Padmanabhan, S, Palmas, WR, Palmer, ND, Pankow, JS, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Raitakari, OT, Renström, F, Rice, TK, Ridker, PM, Robino, A, Robinson, JG, Rose, LM, Rudan, I, Sabanayagam, C, Salako, BL, Sandow, K, Schmidt, CO, Schreiner, PJ, Scott, WR, Seshadri, S, Sever, P, Sitlani, CM, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Tang, H, Taylor, KD, Teo, YY, Tham, YC, Uitterlinden, AG, Waldenberger, M, Wang, L, Wang, YX, Wei, WB, Williams, C, Wilson, G, Wojczynski, MK, Yao, J, Yuan, J-M, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Chen, Y-DI, de Faire, U, Deary, IJ, Esko, T, Farrall, M, Forrester, T, Franks, PW, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BL, Hung, Y-J, Jonas, JB, Kato, N, Kooner, JS, Laakso, M, Lehtimäki, T, Liang, K-W, Magnusson, PKE, Newman, AB, Oldehinkel, AJ, Pereira, AC, Redline, S, Rettig, R, Samani, NJ, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, LE, Wareham, NJ, Watkins, H, Weir, DR, Wickremasinghe, AR, Wu, T, Zheng, W, Kamatani, Y, Laurie, CC, Bouchard, C, Cooper, RS, Evans, MK, Gudnason, V, Kardia, SLR, Kritchevsky, SB, Levy, D, O'Connell, JR, Psaty, BM, van Dam, RM, Sims, M, Arnett, DK, Mook-Kanamori, DO, Kelly, TN, Fox, ER, Hayward, C, Fornage, M, Rotimi, CN, Province, MA, van Duijn, CM, Tai, ES, Wong, TY, Loos, RJF, Reiner, AP, Rotter, JI, Zhu, X, Bierut, LJ, Gauderman, WJ, Caulfield, MJ, Elliott, P, Rice, K, Munroe, PB, Morrison, AC, Cupples, LA, Rao, DC, Chasman, DI
Format: Journal article
Language:English
Published: Cell Press 2018