The ubiquitin-proteasome pathway is dysregulated in myeloma cells in the bone microenvironment in vivo

The ubiquitin-proteasome pathway is dysregulated in myeloma cells in the bone microenvironment in vivo

Xehetasun bibliografikoak
Egile Nagusiak:	Edwards, C, Fowler, J, Caldwell, R, Bates, A, Edwards, JR, Zhang, J, Foehr, D, Parker, R, Roberts, A, Mundy, G
Formatua:	Conference item
Argitaratua:	2007

Antzeko izenburuak

Myeloma cells exhibit an increase in proteasome activity and an enhanced response to proteasome inhibition in the bone marrow microenvironment in vivo.
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Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo.
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Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1.
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Lithium inhibits the development of myeloma bone disease in vivo.
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Increasing adiponectin via an apolipoprotein peptide mimetic, L-4F, increases bone formation in normal mice and prevents myeloma bone disease in vivo
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Myeloma cells decrease EphB4 expression in osteoblasts: A novel mechanism for regulation of bone formation in multiple myeloma
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The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo
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Host-derived MMP-7 decreases myeloma progression in vivo: An unexpected role for MMP-7 and osteopontin in myeloma pathogenesis
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Host Bone Marrow-Derived Stromal Cells Promote Myeloma Initiation and Development of Osteolysis
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The pathogenesis of the bone disease of multiple myeloma.
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The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo
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Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease.
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A loss of host-derived MMP-7 promotes myeloma growth and osteolytic bone disease in vivo
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Osteoclasts in myeloma are derived from Gr-1+CD11b+mononuclear cells of the bone marrow niche
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#38. Cholesterol increases bone marrow tumour burden in myeloma in vivo and promotes myeloma cell viability and bortezomib resistance ex vivo
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Tumor-host cell interactions in the bone disease of myeloma.
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Diet-induced obesity promotes a myeloma-like condition in vivo.
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EphB4 Expression in Osteoblasts is Regulated by Myeloma Cells and the Wnt Signaling Pathway.
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Agonists of TRAIL death receptors induce myeloma cell apoptosis that is not prevented by cells of the bone marrow microenvironment.
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The ubiquitin-proteasome pathway in cancer.
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Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment
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Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors
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The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease.
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