Regulation of tumor pH and the role of carbonic anhydrase 9.
The high metabolic rate required for tumor growth often leads to hypoxia in poorly-perfused regions. Hypoxia activates a complex gene expression program, mediated by hypoxia inducible factor 1 (HIF1alpha). One of the consequences of HIF1alpha activation is up-regulation of glycolysis and hence the p...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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