Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria

Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria

An oral Controlled Human Infection Model (CHIM) with wild-type S. Typhi was re-established allowing us to explore the development of immunity. In this model, ~55% of volunteers who received the challenge reached typhoid diagnosis criteria (TD), while ~45% did not (NoTD). Intestinal macrophages are o...

Полное описание

Библиографические подробности
Главные авторы:	Toapanta, FR, Hu, J, Shirey, KA, Bernal, PJ, Levine, MM, Darton, TC, Waddington, CS, Pollard, AJ, Sztein, MB
Формат:	Journal article
Язык:	English
Опубликовано:	Frontiers Media 2024

Схожие документы

Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria
по: Franklin R. Toapanta, и др.
Опубликовано: (2024-08-01)

Oral challenge with wild-type Salmonella Typhi induces distinct changes in B cell subsets in individuals who develop typhoid disease.
по: Toapanta, F, и др.
Опубликовано: (2016)

Oral wild-type Salmonella Typhi challenge induces activation of circulating monocytes and dendritic cells in individuals who develop typhoid disease
по: Toapanta, F, и др.
Опубликовано: (2015)

Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease.
по: Franklin R Toapanta, и др.
Опубликовано: (2016-06-01)

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.
по: Franklin R Toapanta, и др.
Опубликовано: (2015-06-01)

Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S. Typhi in humans
по: Booth, JS, и др.
Опубликовано: (2024)

Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model.
по: McArthur, M, и др.
Опубликовано: (2015)

Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model
по: Fresnay, S, и др.
Опубликовано: (2017)

Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model.
по: Monica A McArthur, и др.
Опубликовано: (2015-05-01)

Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever
по: Salerno-Gonçalves, R, и др.
Опубликовано: (2022)

Human Salmonella Typhi exposure generates differential multifunctional cross-reactive T-cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella
по: Rapaka, RR, и др.
Опубликовано: (2020)

Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans
по: Fresnay, S, и др.
Опубликовано: (2016)

Demonstration of primary and asymptomatic DNAaemia in participants challenged with Salmonella Typhi (Quailes strain) during the development of a human model of typhoid infection
по: Darton, T, и др.
Опубликовано: (2012)

Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S. Typhi in humans
по: Jayaum S. Booth, и др.
Опубликовано: (2024-09-01)

Advancing the management and control of typhoid fever: A review of the historical role of human challenge studies
по: Waddington, C, и др.
Опубликовано: (2014)

Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization.
по: Monica A McArthur, и др.
Опубликовано: (2012-01-01)

In Vitro intestinal mucosal epithelial responses to wild-typeSalmonella Typhi and attenuated typhoid vaccines
по: Maria eFiorentino, и др.
Опубликовано: (2013-02-01)

Variations in attack rate in a single-blind, dose escalation challenge study of Salmonella Typhi in healthy adult volunteers
по: Waddington, C, и др.
Опубликовано: (2012)

Quantification of antibody secreting cell responses in a human challenge model of Salmonella Typhi infection
по: Jones, C, и др.
Опубликовано: (2012)

Advancing the management and control of typhoid fever: a review of the historical role of human challenge studies.
по: Waddington, C, и др.
Опубликовано: (2014)

Challenge of humans with wild-type Salmonella enterica serovar Typhi elicits changes in the activation and homing characteristics of mucosal-associated invariant T cells.
по: Salerno-Goncalves, R, и др.
Опубликовано: (2017)

Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella
по: Rekha R Rapaka, и др.
Опубликовано: (2020-01-01)

Typhoid epidemiology, diagnostics and the human challenge model.
по: Darton, T, и др.
Опубликовано: (2014)

Dealing with Foodborne Illness: Typhoid Fever, Salmonella Typhi
по: Karen Carver, и др.
Опубликовано: (2005-08-01)

Preventing Foodborne Illness: Typhoid Fever—Salmonella Typhi
по: Keith R. Schneider, и др.
Опубликовано: (2016-02-01)

Salmonella Typhi genomics: envisaging the future of typhoid eradication
по: Yap, K.P., и др.
Опубликовано: (2017)

Dealing with Foodborne Illness: Typhoid Fever, Salmonella Typhi
по: Karen Carver, и др.
Опубликовано: (2005-08-01)

Preventing Foodborne Illness: Typhoid Fever—Salmonella Typhi
по: Keith R. Schneider, и др.
Опубликовано: (2016-02-01)

Preventing Foodborne Illness: Typhoid Fever—Salmonella Typhi
по: Keith R. Schneider, и др.
Опубликовано: (2016-02-01)

Dealing with Foodborne Illness: Typhoid Fever, Salmonella Typhi
по: Karen Carver, и др.
Опубликовано: (2005-08-01)

Mix-infection of S. Typhi and ParaTyphi A in Typhoid Fever and Chronic Typhoid Carriers: A Nested PCR Based Study in North India
по: Chandra Bhan Pratap, и др.
Опубликовано: (2014-11-01)

An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever
по: Tran Vu Thieu, N, и др.
Опубликовано: (2017)

A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid
по: Britto, C, и др.
Опубликовано: (2018)

A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.
по: Carl D Britto, и др.
Опубликовано: (2018-10-01)

Salmonella typhi bactericidal antibodies reduce disease severity but do not protect against typhoid fever in a controlled human infection model
по: Juel, H, и др.
Опубликовано: (2018)

Understanding typhoid disease; a controlled human infection model of typhoid fever
по: Waddington, C, и др.
Опубликовано: (2014)

Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia.
по: Darton, T, и др.
Опубликовано: (2017)

Towards a refined definition of monocyte subsets
по: Loems eZiegler-Heitbrock, и др.
Опубликовано: (2013-02-01)

Why the development of effective typhoid control measures requires the use of human challenge studies.
по: Jones, C, и др.
Опубликовано: (2014)

Application of a challenge model to assess the protective efficacy of oral typhoid vaccines in humans
по: Darton, T, и др.
Опубликовано: (2014)