Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials

Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of therapeutic interest. We describe cellular, biophysical, and biochemical studies comparing four PHD i...

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Bibliographic Details
Main Authors: Yeh, TL, Leissing, TM, Abboud, M, Thinnes, CC, Atasoylu, O, Holt-Martyn, JP, Zhang, D, Tumber, A, Lippl, K, Lohans, CT, Leung, IKH, Morcrette, H, Kawamura, A, Flashman, E, Lu, X, Ratcliffe, P, Chowdhury, R, Pugh, C, Schofield, C
Format: Journal article
Published: Royal Society of Chemistry 2017

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