Cell proliferation is a key determinant of the outcome of FOXO3a activation.

The FOXO family of forkhead transcription factors have a pivotal role in determining cell fate in response to oxidative stress. FOXO activity can either promote cell survival or induce cell death. Increased FOXO-mediated cell death has been implicated in the pathogenesis of degenerative diseases aff...

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Bibliografiske detaljer
Main Authors: Poulsen, R, Carr, A, Hulley, P
Format: Journal article
Sprog:English
Udgivet: 2015