A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.

Drosophila has three membrane-tethered epidermal growth factor (EGF)-like proteins: Spitz, Gurken and Keren. Spitz and Gurken have been genetically confirmed to activate the EGF receptor, but Keren is uncharacterized. Spitz is activated by regulated intracellular translocation and cleavage by the tr...

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Detalhes bibliográficos
Principais autores:	Urban, S, Lee, JR, Freeman, M
Formato:	Journal article
Idioma:	English
Publicado em:	2002

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