Mutations in the SMAD4/DPC4 gene in juvenile polyposis.

Mutations in the SMAD4/DPC4 gene in juvenile polyposis.

Familial juvenile polyposis is an autosomal dominant disease characterized by a predisposition to hamartomatous polyps and gastrointestinal cancer. Here it is shown that a subset of juvenile polyposis families carry germ line mutations in the gene SMAD4 (also known as DPC4), located on chromosome 18...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Howe, JR, Roth, S, Ringold, J, Summers, R, Järvinen, H, Sistonen, P, Tomlinson, I, Houlston, R, Bevan, S, Mitros, F, Stone, E, Aaltonen, L
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	1998

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