Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
Familial juvenile polyposis is an autosomal dominant disease characterized by a predisposition to hamartomatous polyps and gastrointestinal cancer. Here it is shown that a subset of juvenile polyposis families carry germ line mutations in the gene SMAD4 (also known as DPC4), located on chromosome 18...
Autori principali: | , , , , , , , , , , , |
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Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
1998
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