Proteasome inhibitors as anti-cancer agents.
The ubiquitin (Ub)-proteasome pathway is the major nonlysosomal pathway of proteolysis in human cells and accounts for the degradation of most short-lived, misfolded or damaged proteins. This pathway is important in the regulation of a number of key biological regulatory mechanisms. Proteins are usu...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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