Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% C...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Yeager, M, Chatterjee, N, Ciampa, J, Jacobs, K, Gonzalez-Bosquet, J, Hayes, R, Kraft, P, Wacholder, S, Orr, N, Berndt, S, Yu, K, Hutchinson, A, Wang, Z, Amundadottir, L, Feigelson, H, Thun, M, Diver, W, Albanes, D, Virtamo, J, Weinstein, S, Schumacher, F, Cancel-Tassin, G, Cussenot, O, Valeri, A, Andriole, G
Format: Journal article
Sprache:English
Veröffentlicht: 2009
Beschreibung
Zusammenfassung:We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.