Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.
Although originally discovered as inhibitors of pencillin-binding proteins, beta-lactams have more recently found utility as serine protease inhibitors. Indeed through their ability to react irreversibly with nucleophilic serine residues they have proved extraordinarily successful as enzyme inhibito...
المؤلفون الرئيسيون: | Wilmouth, R, Kassamally, S, Westwood, N, Sheppard, R, Claridge, T, Aplin, RT, Wright, P, Pritchard, G, Schofield, C |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
1999
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مواد مشابهة
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Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.
حسب: Wilmouth, R, وآخرون
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Reaction of clavams with elastase reveals a general method for inhibiting 'serine' enzymes
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5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
حسب: Migaud, M, وآخرون
منشور في: (2002) -
5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
حسب: Migaud, M, وآخرون
منشور في: (2002) -
Enzymatic synthesis of monocyclic beta-lactams.
حسب: Sleeman, M, وآخرون
منشور في: (2002)