Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.

Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.

Although originally discovered as inhibitors of pencillin-binding proteins, beta-lactams have more recently found utility as serine protease inhibitors. Indeed through their ability to react irreversibly with nucleophilic serine residues they have proved extraordinarily successful as enzyme inhibito...

Полное описание

Библиографические подробности
Главные авторы:	Wilmouth, R, Kassamally, S, Westwood, N, Sheppard, R, Claridge, T, Aplin, RT, Wright, P, Pritchard, G, Schofield, C
Формат:	Journal article
Язык:	English
Опубликовано:	1999

Схожие документы

Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.
по: Wilmouth, R, и др.
Опубликовано: (1998)

Reaction of clavams with elastase reveals a general method for inhibiting 'serine' enzymes
по: Wilmouth, R, и др.
Опубликовано: (2000)

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
по: Migaud, M, и др.
Опубликовано: (2002)

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
по: Migaud, M, и др.
Опубликовано: (2002)

Enzymatic synthesis of monocyclic beta-lactams.
по: Sleeman, M, и др.
Опубликовано: (2002)

Structural analyses on intermediates in serine protease catalysis.
по: Liu, B, и др.
Опубликовано: (2006)

Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.
по: Pierrat, O, и др.
Опубликовано: (2011)

Advances in synthesis of monocyclic beta-lactams
по: Girija S. Singh, и др.
Опубликовано: (2014-05-01)

Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors
по: Westwood, N, и др.
Опубликовано: (1997)

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.
по: Wilmouth, R, и др.
Опубликовано: (2001)

beta-Sultams - A novel class of serine protease inhibitors
по: Beardsell, M, и др.
Опубликовано: (2001)

X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution.
по: Katona, G, и др.
Опубликовано: (2002)

Substituted-Amidine Functionalized Monocyclic β-Lactams: Synthesis and In Vitro Antibacterial Profile
по: Lili He, и др.
Опубликовано: (2021-01-01)

Synthesis of Novel N-Sulfonyl Monocyclic ÃŽÂ²-Lactams as Potential Antibacterial Agents
по: Maaroof Zarei, и др.
Опубликовано: (2006-01-01)

Synthesis and Antimicrobial Activity of Some New Sugar-Based Monocyclic ÃŽÂ²-Lactams
по: A. Taslimi, и др.
Опубликовано: (2004-01-01)

'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes.
по: Wright, P, и др.
Опубликовано: (2000)

New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
по: McDonough, M, и др.
Опубликовано: (2003)

Mechanistic studies on regulation of the activity of GPI-anchored serine protease testisin
по: WAN Jiahui, и др.
Опубликовано: (2024-12-01)

Monocyclic β-lactams loaded on hydroxyapatite: new biomaterials with enhanced antibacterial activity against resistant strains
по: Daria Giacomini, и др.
Опубликовано: (2017-06-01)

Facile synthesis of novel monocyclic trans- and cis-3-oxo/thio/seleno-4-pyrazolyl-β-lactams
по: Aman Bhalla, и др.
Опубликовано: (2015-08-01)

Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s)
по: Grabrijan Katarina, и др.
Опубликовано: (2024-09-01)

Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.
по: Wilmouth, R, и др.
Опубликовано: (1997)

New Insights into Beta-Lactam Resistance of <i>Streptococcus pneumoniae</i>: Serine Protease HtrA Degrades Altered Penicillin-Binding Protein 2x
по: Katharina Peters, и др.
Опубликовано: (2021-08-01)

Bacterial degradation of monocyclic aromatic amines
по: Pankaj Kumar Arora
Опубликовано: (2015-08-01)

Synthesis of monocyclic diaziridines and their fused derivatives
по: Nina N. Makhova, и др.
Опубликовано: (2008-05-01)

Genome-wide survey of prokaryotic serine proteases: Analysis of distribution and domain architectures of five serine protease families in prokaryotes
по: Tripathi Lokesh P, и др.
Опубликовано: (2008-11-01)

New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina
по: Zhang Ying, и др.
Опубликовано: (2010-03-01)

Bicyclic lactams derived from serine or cysteine and 2-methylpropanal
по: Bagum, H, и др.
Опубликовано: (2020)

Global atmospheric budget of simple monocyclic aromatic compounds
по: D. Cabrera-Perez, и др.
Опубликовано: (2016-06-01)

Stereoselective Synthesis of a New cis Monocyclic β-lactam Bearing a Sugar Moiety at Its N1 Position and Its Physical Characterization
по: Parvaneh Alvand, и др.
Опубликовано: (2007-05-01)

Serine protease inhibitors and human wellbeing interplay: new insights for old friends
по: Héla Mkaouar, и др.
Опубликовано: (2019-08-01)

Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines
по: Olivares, Adrian O., и др.
Опубликовано: (2017)

The new external drug for the treatment of psoriasis based on inhibition of serine proteases
по: Alexander S. Zhukov, и др.
Опубликовано: (2021-07-01)

Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases.
по: Topf, M, и др.
Опубликовано: (2002)

Commentary: Fungal lifestyle reflected in serine protease repertoire
по: Ronivaldo R. da Silva
Опубликовано: (2018-03-01)

Cross genome comparisons of serine proteases in Arabidopsis and rice
по: Sowdhamini R, и др.
Опубликовано: (2006-08-01)

Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
по: Lohans, C, и др.
Опубликовано: (2018)

¹⁹F NMR studies on 𝛾-Butyrobetaine Hydroxylase provide mechanistic insights and suggest a dual inhibition mode
по: Leśniak, RK, и др.
Опубликовано: (2019)

The behavioral sensitivity of mice to acyclic, monocyclic, and bicyclic monoterpenes.
по: Ellie Williams, и др.
Опубликовано: (2024-01-01)

The behavioral sensitivity of mice to acyclic, monocyclic, and bicyclic monoterpenes
по: Ellie Williams, и др.
Опубликовано: (2024-01-01)