Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.

Although originally discovered as inhibitors of pencillin-binding proteins, beta-lactams have more recently found utility as serine protease inhibitors. Indeed through their ability to react irreversibly with nucleophilic serine residues they have proved extraordinarily successful as enzyme inhibito...

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Bibliografiska uppgifter
Huvudupphovsmän: Wilmouth, R, Kassamally, S, Westwood, N, Sheppard, R, Claridge, T, Aplin, RT, Wright, P, Pritchard, G, Schofield, C
Materialtyp: Journal article
Språk:English
Publicerad: 1999