303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Nitric oxide (NO), produced by endothelial NO synthase (NOS) is a key regulator of vascular tone and blood pressure. Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial NOS. When BH4 levels become limiting, eNOS produces superoxide anion rather than NO and in turn further reduces NO b...
Հիմնական հեղինակներ: | Chuaiphichai, S, Mcneill, E, Douglas, G, Crabtree, M, Bendall, J, Hale, A, Alp, N, Channon, K |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2014
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Նմանատիպ նյութեր
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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
: Chuaiphichai, S, և այլն
Հրապարակվել է: (2014) -
Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
: Chuaiphichai, S, և այլն
Հրապարակվել է: (2014) -
Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth
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GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
: Tatham, A, և այլն
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Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
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Հրապարակվել է: (2012)